In this course, participants will learn advanced clinical approaches to diagnosing and differentiating clinical presentations of anxiety, depression, bipolar, and personality disorders. Differential diagnosis will be emphasized, and decision-making about treatment with medications and/or psychotherapies, and which specific ones, will be discussed in detail. The presentation will be very interactive, and consistently clinical and related to concrete cases. Emphasis will be placed on a little understood and used approach: the existential/humanistic methods of psychotherapy. The overall approach will be an integrated way of thinking about mental health practice that goes beyond simplicities of DSM definitions, FDA-indication based use of drugs and eclectic psychotherapies. A more integrative approach will be offered that is scientific without being reductionistic and humanistic without being vague.